Co-exposure to sand fly saliva and filarial parasites exhibit altered monocyte function

Updated: Jul 2, 2021

Threads Lab PhD Student Moussa Sangare's paper shows that monocytes of unexposed individuals selectively upregulated the production of IL-6 and CCL4 in response to salivary gland from Phlebotomus duboscqi or other vector species. While repeated exposure to Phlebotomus duboscqi saliva alters human monocyte function towards a tolerized phenotype, co-infection with filaria favours a Leishmania-promoting Th2/regulatory response.



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